Weis et al., J Clin Invest, 2004

Ischemia resulting from myocardial infarction (MI) promotes VEGF expression, leading to vascular permeability (VP) and edema, a process that we show here contributes to tissue injury throughout the ventricle. This permeability/edema can be assessed noninvasively by MRI and can be observed at the ultrastructural level as gaps between adjacent endothelial cells. Many of these gaps contain activated platelets adhering to exposed basement membrane, reducing vessel patency. Following MI, genetic or pharmacological blockade of Src preserves endothelial cell barrier function, suppressing VP and infarct volume,

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Yoon and Losordo, Circ Res, 2003

Ischemic disease is the leading cause of morbidity and mortality in the United States, accounting for almost 50% of overall mortality, and endothelial dysfunction is a key pathophysiological process that underlies both myocardial and peripheral ischemia. The prevalence of peripheral arterial disease is 12% in the United States, where 150 000 patients undergo lower-limb amputations every year. The overall prognosis after amputation is guarded at best, given a perioperative mortality rate of 5% to 20% and 2-year follow-up mortality rate of 40%. For those patients who have advanced ischemic cardiac or peripheral

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Goukassian et al., Circ Res, 2003

Tumor necrosis factor-alpha (TNF-alpha) is expressed locally in the vessel wall after angioplasty and induces growth arrest and apoptosis in endothelial cells (ECs), thereby delaying reendothelialization. Prior studies have shown that direct antagonism of TNF-alpha, using a systemically administered soluble receptor, can enhance endothelial recovery and reduce neointimal thickening. These studies have also shown that downregulation of the transcription factor E2F1 was a key mechanism of TNF’s effect on ECs. We now show that Ad-E2F1 overexpression at sites of balloon injury accelerates functional endothelial recovery,

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Yoon et al., J Clin Invest, 2003

Although lymphedema is a common clinical condition, treatment for this disabling condition remains limited and largely ineffective. Recently, it has been reported that overexpression of VEGF-C correlates with increased lymphatic vessel growth (lymphangiogenesis). However, the effect of VEGF-C-induced lymphangiogenesis on lymphedema has yet to be demonstrated. Here we investigated the impact of local transfer of naked plasmid DNA encoding human VEGF-C (phVEGF-C) on two animal models of lymphedema: one in the rabbit ear and the other in the mouse tail. In a rabbit model, following local phVEGF-C

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Kawamoto et al., Circulation, 2003

We investigated whether catheter-based, intramyocardial transplantation of autologous endothelial progenitor cells can enhance neovascularization in myocardial ischemia. Myocardial ischemia was induced by placement of an ameroid constrictor around swine left circumflex artery. Four weeks after constrictor placement, CD31+ mononuclear cells (MNCs) were freshly isolated from the peripheral blood of each animal. After overnight incubation of CD31+ MNCs in noncoated plates, nonadhesive cells (NA/CD31+ MNCs) were harvested as the endothelial progenitor cell-enriched fraction. Nonadhesive CD31- cells

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Dr. Yoon Honored for Emory University’s Innovation of 2012

Young-sup Yoon, MD, PhD, was honored March 7 at the seventh annual “Celebration of Technology and Invention” hosted by the Emory Office of Technology Transfer. This event recognizes successful technologies and inventions from the past year. Yoon, a Professor of Medicine in the Division of Cardiology, received Emory University’s Innovation of 2012 award for his technology entitled “Generation of Transgene-free Induced […]

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Kyuwon Cho, granted admission to Emory Graduate School

Current Yoon lab research assistant, Kyuwon Cho, got accepted into The Molecular and Systems Pharmacology Graduate program (MSP) at Emory University. MSP program at Emory University offers broad training in the biomedical sciences for students interested in learning how the drugs of today work and how the novel therapeutics of tomorrow can be developed. Emory […]

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Dabin Choi, acceptance into the 2013 Petit Undergraduate Research Scholars Program

Yoon lab undergraduate volunteer Dabin Choi, who is a second-year student at Emory University, was accepted into the 2013 Petit Undergraduate Research Scholars Program at Georgia Tech. The Petit Undergraduate Research Scholars program is a competitive scholarship program that serves to develop the next generation of leading bioengineering and bioscience researchers by providing a comprehensive […]

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Top Downloaded Online First Article in Circulation Research, Aug 2011

The editors of Circulation Research wish to congratulate us for having published one of the most downloaded articles in Circulation Research journal. During April 2011, our Online First article, “Malignant Tumor Formation After Transplantation of Short-Term Cultured Bone Marrow Mesenchymal Stem Cells in Experimental Myocardial Infarction and Diabetic Neuropathy,” was downloaded and viewed over 585 […]

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