Cho and Yoon, Circ Res, 2006

Circ Res. 2006 Apr 28;98(8):990-2.

Synergism of hematopoietic cytokines for infarct repair.

Over the past few years, the field of stem cell biology and its therapeutic application in cardiovascular diseases has expanded remarkably and moved to the forefront of cardiovascular science. Promising results from experimental studies with bone marrow (BM)-derived stem or progenitor cells prompted initiation of clinical trials in ischemic heart diseases (IHD). Pilot clinical trials demonstrated that cell therapy using various BM-derived cells are safe and effective for treating IHD. The discovery that BM includes various stem cells spawned the strategy of directly mobilizing and homing BM cells into the heart to regenerate injured tissue.6 This concept is appealing because invasive procedures related to harvesting and delivering BM cells into the heart can be avoided.

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Categories: 2006