Lee et al., Exp Hematol, 2006
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Exp Hematol. 2006 Nov;34(11):1602-3.
Derivation and characterization of bone marrow-derived multipotent stem cells.
Division of Cardiovascular Research, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
We have identified a subpopulation of stem cells within adult human bone marrow (BM), isolated at the single-cell level, that self-renew without loss of multipotency for more than 6 to 9 months of continuous cultures and exhibit the capacity for differentiation into cells of three germ layers. Based on surface marker expression, these clonally expanded human bone marrow-derived multipotent stem cells (hBMSCs) do not appear to belong to previously described BM-derived stem or progenitor cell populations.