Review Theranostics. 2022 Mar 14;12(6):2758-2772. doi: 10.7150/thno.67661. eCollection 2022. From engineered heart tissue to cardiac organoid Jaeyeaon Cho 1 2, Hyein Lee 2 3, Woongchan Rah 2, Hyuk Jae Chang 4 3, Young-Sup Yoon 1 2 5Affiliations expand PMID: 35401829 PMCID: PMC8965483 DOI: 10.7150/thno.67661 Abstract The advent of human pluripotent stem cells (hPSCs) presented a new paradigm to employ hPSC-derived cardiomyocytes (hPSC-CMs) in drug screening and disease modeling. However, hPSC-CMs differentiated in conventional two-dimensional systems are structurally […]

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