Review Theranostics. 2022 Mar 14;12(6):2758-2772. doi: 10.7150/thno.67661. eCollection 2022. From engineered heart tissue to cardiac organoid Jaeyeaon Cho 1 2, Hyein Lee 2 3, Woongchan Rah 2, Hyuk Jae Chang 4 3, Young-Sup Yoon 1 2 5Affiliations expand PMID: 35401829 PMCID: PMC8965483 DOI: 10.7150/thno.67661 Abstract The advent of human pluripotent stem cells (hPSCs) presented a new paradigm to employ hPSC-derived cardiomyocytes (hPSC-CMs) in drug screening and disease modeling. However, hPSC-CMs differentiated in conventional two-dimensional systems are structurally […]

Nat Biomed Eng. 2021 Aug;5(8):880-896. doi: 10.1038/s41551-021-00783-0. Epub 2021 Aug 23. Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts Jaeyeaon Cho 1 2, Sangsung Kim 2, Hyein Lee 2, Woongchan Rah 2, Hee Cheol Cho 3, Nam Kyun Kim 3, Seongho Bae 1, Dong Hoon Shin 2, Min Goo Lee 4, In-Hyun Park 5, Yoshiaki Tanaka 6, Eric Shin 1, Hong Yi 7, Ji Woong Han 1, Patrick Tae Joon Hwang 8, Ho-Wook Jun 8, Hun-Jun Park 9, Kyuwon Cho 1, Sang Wook Lee 1, Jae Kyung Jung 1, Rebecca D […]

Sci Rep. 2020 May 15;10(1):8061. doi: 10.1038/s41598-020-64908-2. Mammalian CBX7 isoforms p36 and p22 exhibit differential responses to serum, varying functions for proliferation, and distinct subcellular localization Kyu-Won Cho # 1, Mark Andrade # 1, Yu Zhang 1, Young-Sup Yoon 2 3 4 PMID: 32415167 PMCID: PMC7228926 DOI: 10.1038/s41598-020-64908-2 Abstract CBX7 is a polycomb group protein, and despite being implicated in many diseases, its role in cell proliferation has been controversial: some […]

Circ Res. 2019 Dec 6;125(12):1141-1145. doi: 10.1161/CIRCRESAHA.119.310859. Epub 2019 Dec 5. Current State of Cardiovascular Research in Korea Jae Il Shin 1 2, Jaewon Oh 3, Hyeon Chang Kim 4, Donghoon Choi 3, Young-Sup Yoon 5 2Affiliations expand PMID: 31804914 PMCID: PMC7008968 DOI: 10.1161/CIRCRESAHA.119.310859 Free PMC article Abstract Cardiovascular diseases have shown a continuous increase in Korea over the past decade and became the second most common cause of mortality in Korea. Although […]

Nat Methods. 2019 Nov;16(11):1169-1175. doi: 10.1038/s41592-019-0586-5. Epub 2019 Oct 7. Engineering of human brain organoids with a functional vascular-like system Bilal Cakir # 1, Yangfei Xiang # 1, Yoshiaki Tanaka 1, Mehmet H Kural 2, Maxime Parent 3, Young-Jin Kang 4 5, Kayley Chapeton 6, Benjamin Patterson 1, Yifan Yuan 2, Chang-Shun He 7, Micha Sam B Raredon 2 7, Jake Dengelegi 8, Kun-Yong Kim 1, Pingnan Sun 1, Mei Zhong 9, Sangho Lee 10, Prabir Patra 1 8, Fahmeed Hyder 3 7, Laura E Niklason 2 7, Sang-Hun Lee 4 5, Young-Sup Yoon 10 11, In-Hyun Park 12Affiliations expand PMID: 31591580 PMCID: PMC6918722 DOI: 10.1038/s41592-019-0586-5 Abstract Human cortical organoids (hCOs), derived from human […]